From British Journal of Dermatology
Background: Previous reports have suggested that certain probiotics given to mothers and children at risk of atopy halves the incidence of atopic dermatitis (AD) at two years of age.
Objectives: The purpose of this trial was to examine if probiotics given to pregnant women in a non-selected population could prevent atopic sensitization or allergic diseases during the child’s first two years.
Methods: In a randomised, double-blind trial of children from a non-selected maternal population (ClinicalTrials.gov identifier: NCT00159523), women received probiotic milk or placebo from 36 weeks of gestation to three months postnatally during breastfeeding. The probiotic milk contained Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. Children with an itchy rash for more than four weeks were consecutively assessed for AD. At two years of age, all children were assessed for atopic sensitisation, AD, asthma and allergic rhinoconjunctivitis (ARC). The intention-to-treat (ITT) analysis was enabled by multiple imputations. Read the rest of this entry