Maternal Care Archives

Myths and Truths Obesity and Pregnancy

Vitamins, weight gain, preterm birth and more

Ironically, despite excessive caloric intake, many obese women are deficient in vitamins vital to a healthy pregnancy. This and other startling statistics abound when obesity and pregnancy collide. Together, they present a unique set of challenges that women and their doctors must tackle in order to achieve the best possible outcome for mom and baby.

In the December issue of the journal Seminars in Perinatology, maternal fetal medicine expert Loralei L. Thornburg, M.D., reviews many of the pregnancy-related changes and obstacles obese women may face before giving birth. The following myths and truths highlight some expected and some surprising issues to take into account before, during and after pregnancy.

“I treat obese patients all the time, and while everything may not go exactly as they’d planned, they can have healthy pregnancies,” said Thornburg, who specializes in the care of high-risk pregnancies and conducts research on obesity and pregnancy. “While you can have a successful pregnancy at any size, women need to understand the challenges that their weight will create and be a partner in their own care; they need to talk with their doctors about the best way to optimize their health and the health of their baby.”

Myth or Truth?

Many obese women are vitamin deficient.

True

Forty percent are deficient in iron, 24 percent in folic acid and 4 percent in B12. This is a concern because certain vitamins, like folic acid, are very important before conception, lowering the risk of cardiac problems and spinal defects in newborns. Other vitamins, such as calcium and iron, are needed throughout pregnancy to help babies grow.

Thornburg says vitamin deficiency has to do with the quality of the diet, not the quantity. Obese women tend to stray away from fortified cereals, fruits and vegetables, and eat more processed foods that are high in calories but low in nutritional value.

“Just like everybody else, women considering pregnancy or currently pregnant should get a healthy mix of fruits and vegetables, lean proteins and good quality carbohydrates. Unfortunately, these are not the foods people lean towards when they overeat,” noted Thornburg. “Women also need to be sure they are taking vitamins containing folic acid before and during pregnancy.”

Obese patients need to gain at least 15 pounds during pregnancy.

Myth

In 2009, the Institute of Medicine revised its recommendations for gestational weight gain for obese women from “at least 15 pounds” to “11-20 pounds.” According to past research, obese women with excessive weight gain during pregnancy have a very high risk of complications, including indicated preterm birth, cesarean delivery, failed labor induction, large-for-gestational-age infants and infants with low blood sugar.

If a woman starts her pregnancy overweight or obese, not gaining a lot of weight can actually improve the likelihood of a healthy pregnancy, Thornburg points out. Talking with your doctor about appropriate weight gain for your pregnancy is key, she says.

The risk of spontaneous preterm birth is higher in obese than non-obese women.

Myth

Obese women have a greater likelihood of indicated preterm birth – early delivery for a medical reason, such as maternal diabetes or high blood pressure. But, paradoxically, the risk of spontaneous preterm birth – when a woman goes into labor for an unknown reason – is actually 20 percent lower in obese than non-obese women. There is no established explanation for why this is the case, but Thornburg says current thinking suggests that this is probably related to hormone changes in obese women that may decrease the risk of spontaneous preterm birth.

Respiratory disease in obesity – including asthma and obstructive sleep apnea – increases the risk for non-pulmonary pregnancy complications, such as cesarean delivery and preeclampsia (high blood pressure).

True

Obese women have increased rates of respiratory complications, and up to 30 percent experience an exacerbation of their asthma during pregnancy, a risk almost one-and-a-half times more than non-obese women. According to Thornburg, respiratory complications represent just one piece of the puzzle that adds to poor health in obesity, which increases the likelihood of problems in pregnancy. She stresses the importance of getting asthma and any other respiratory conditions under control before getting pregnant.

Breastfeeding rates are high among obese women.

Myth

Breastfeeding rates are poor among obese women, with only 80 percent initiating and less than 50 percent continuing beyond six months, even though it is associated with less postpartum weight retention and should be encouraged as it benefits the health of mom and baby.

Thornburg acknowledges that it can be challenging for obese women to breast feed. It often takes longer for their milk to come in and they can have lower production (breast size has nothing to do with the amount of milk produced). Indicated preterm birth can result in prolonged separations of mom and baby as infants are admitted to the neonatal intensive care unit or NICU. This, coupled with the higher rate of maternal complications and cesarean delivery – up to 50 percent in some studies – in obese women, can make it harder to successfully breast feed.

“Because of these challenges, mothers need to be educated, motivated and work with their doctors, nurses and lactation professionals to give breast feeding their best shot. Even if you can only do partial breastfeeding, that is still better than no breastfeeding at all,” said Thornburg.

Preventing Preeclampsia

A new study was released from the British Medical Journal showed the benefit of using L-arginine and antioxidants supplements during pregnancy to prevent preeclampsia.   Preeclampsia is a condition that comes on after the 20th week of pregnancy (but often 3rd trimester) where there is high blood pressure (over 140/90) as well as protein in the urine (proteinuria).  Read the rest of this entry

Although almost every woman I’ve helped with fertility was using some sort of Prenatal vitamin/mineral there are two recent studies below that show their benefit.   When undergoing IVF there are large non-physiological quantities of hormones that need to be metabolized and certain minerals such as copper and zinc are used as co-enzymes in their metabolism.   Therefore it is possible that deficiencies can develop.

For any kind of fertility issues I strongly feel that Chinese herbal medicine and acupuncture are superior than modern assisted reproductive technologies (ART) for a majority of cases.   With acupuncture and herbs you not only help the woman conceive, but also to create healthier offspring, as well as support the health of the mother.   However I also prefer to use some sort of whole food multi vitamin and mineral to support general health.  If there have been miscarriages I also use potent antioxidants (not ones found in a multivitamin/mineral) to help reduce oxidative stress.  As shown by one of the studies below oxidative stress can be high in some IVF cases.
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Supplemental DHA Fish Oils During Pregnancy

J Nutr. 2010 Dec 22.

Docosahexaenoic Acid Supplementation from Mid-Pregnancy to Parturition Influenced Breast Milk Fatty Acid Concentrations at 1 Month Postpartum in Mexican Women.

Imhoff-Kunsch B, Stein AD, Villalpando S, Martorell R, Ramakrishnan U.

Nutrition and Health Sciences Program Emory University, Atlanta, GA 30322.

Abstract

(n-3) PUFA, including DHA, are essential for neural development and accumulate extensively in the fetal and infant brain. (n-3) PUFA concentrations in breast milk, which are largely dependent on maternal diet and tissue stores, are correlated with infant PUFA status. We investigated the effect of prenatal DHA supplementation on PUFA concentrations in breast milk at 1 mo postpartum. In a double-blind, randomized, controlled trial conducted in Mexico, pregnant women were supplemented daily with 400 mg DHA or placebo from 18-22 wk gestation to parturition. Fatty acid concentrations in breast milk obtained from 174 women at 1 mo postpartum were determined using GLC and were expressed as % by wt of total detected fatty acids. Breast milk DHA concentrations in the DHA and placebo groups were (mean ± SD) 0.20 ± 0.06 and 0.17 ± 0.07 (P < 0.01), respectively, and those of α-linolenic acid (ALA) were 1.38 ± 0.47 and 1.24 ± 0.46 (P = 0.01), respectively. Concentrations of EPA and arachidonic acid did not differ between groups (P > 0.05). Maternal plasma DHA concentrations at 1 mo postpartum correlated positively with breast milk DHA at 1 mo postpartum in both the placebo and DHA groups (r = 0.4; P < 0.01 for both treatment groups). Prenatal DHA supplementation from 18-22 wk gestation to parturition increased concentrations of DHA and ALA in breast milk at 1 mo postpartum, providing a mechanism through which breast-fed infants could benefit.

DHA Importance During Breast Feeding

For many years I’ve strongly recommended to my perinatal patients that they take a high dose DHA fish oil supplement. DHA is docosahexaenoic acid found in fatty fish which is one of the beneficial longer chain fatty acids we get from fish – the other being EPA (eicosapentaenoic acid). I’m not sure where I first learned of the benefits of DHA for the brain and using it during pregnancy, but it makes sense given the plethora of research on its neurological benefits.

I had my wife take a high DHA fish oil throughout pregnancy and 2 years of breast feeding. The proof is in the pudding as our child will be attending Harvard next fall. He is only 2 years old.
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Stress Reduces Chance of Conceiving

A recent study has shown that women who are the most stressed have the least likely chance to conceive.   Basically stress plays a huge role in conception which is why so many people that try and try to conceive cannot.   Then they go away on vacation and get pregnant.  We’ve heard these stories many times and I and others believe this is true, but the recent study has now given it more credence.

In this study they checked a marker of stress called alpha-amylase.   It is an enzyme made in the mouth that helps us digest carbohydrates.   But it has also been shown to increase during times of Sympathetic Nervous System (SNS) dominance – meaning the flight or fight stage we’ve heard about.   Researchers use this marker for determining the stress response in the body because it is easy to measure and it is quick to respond.    Women who had the most trouble getting pregnant had higher levels of alpha-amylase than women who conceived.
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From British Journal of Dermatology
Background: Previous reports have suggested that certain probiotics given to mothers and children at risk of atopy halves the incidence of atopic dermatitis (AD) at two years of age.

Objectives: The purpose of this trial was to examine if probiotics given to pregnant women in a non-selected population could prevent atopic sensitization or allergic diseases during the child’s first two years.

Methods: In a randomised, double-blind trial of children from a non-selected maternal population (ClinicalTrials.gov identifier: NCT00159523), women received probiotic milk or placebo from 36 weeks of gestation to three months postnatally during breastfeeding. The probiotic milk contained Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. Children with an itchy rash for more than four weeks were consecutively assessed for AD. At two years of age, all children were assessed for atopic sensitisation, AD, asthma and allergic rhinoconjunctivitis (ARC). The intention-to-treat (ITT) analysis was enabled by multiple imputations. Read the rest of this entry

There has been a lot of research about maternal diet and health of offspring recently, but diet is important during pre-conception as well. There have been links to gluten sensitivity and infertility, vitamin D deficiency and infertility, and now there was a study just released that showed a Mediterranean diet can help boot conception rate in couples undergoing IVF.

Fertil Steril.2010 Feb 18
The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy.
Vujkovic M, de Vries JH, Lindemans J, Macklon NS, van der Spek PJ, Steegers EA, Steegers-Theunissen RP.

Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

Research published last week out of Stanford University concluded that acupuncture is an effective treatment for depression during pregnancy. This was reported in Science Daily.

In our clinical practice we certainly find that women who get regular treatments during pregnancy report a much greater well being.   Certainly we’ve helped women stay off anti-depressant medication, which now unfortunately is given as a preventative. Read the rest of this entry

I’d say that all women that come into our office are aware that it is important to supplement with folic acid before they get pregnant and during pregnancy.  Another research study was just released showing benefits of folic acid in relation to growth in-utero.    However because of the negative research studies about supplementing with folic acid (the synthetic form found in 95% of nutritional supplements) I highly recommend using a supplement with the natural form which is folate. Read the rest of this entry

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