Title: A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats

Authors: Kara B. Duffy, Edward L. Spangler, Bryan D. Devan, Zhihong Guo, Jonna L. Bowker, Anne M. Janas, Adrienne Hagepanos, Robin K. Minor, Rafael DeCabo, Peter R. Mouton, Barbara Shukitt-Hale, James A. Joseph, Donald K. Ingram

Abstract: Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.5 μl) or phosphate buffered saline (PBS). One week later rats were trained in one-way active footshock avoidance in a straight runway followed the next day by training in a footshock motivated 14-unit T-maze with documented sensitivity to hippocampal glutamatergic manipulations. Read the rest of this entry